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CBD Isolate VS Full Spectrum CBD

CBD Isolate VS Full Spectrum CBD

These terms might sound rather scientific and a little confusing. Rightly so, because CBD can be quite a complex compound. 

The public awareness of CBD is exploding, but there is still some hesitancy from those that associate it with the stereotypes of cannabis, so we think it is a good idea to explore the different products in more detail. 

In this article we are going to distinguish the difference between CBD isolate and full spectrum CBD, which one is best for each situation, and the way they are incorporated within various products.

Firstly, let’s look at the two contenders and put them into a format that is easier to understand:

What is CBD isolate?

The best way to look at CBD isolate is to consider it as simply “isolated CBD”.

It’s extracted from the cannabis plant and is usually 99.9% pure. It contains no other elements of the cannabis plant; No tastes, no smells, and most importantly, no THC, so has no psychoactive effects.

Short, sweet and simple.


What is full spectrum CBD (Distillate)?

Full spectrum CBD (whole plant extract, or distillate as it is sometimes called) is a carefully extracted collection of the entire cannabis plant’s most therapeutic properties.


Included in these extracted compounds are terpenes. These terpenes are known to offer their very own health benefits!

For example; Linalool (found in Lavender) has strong anti-inflammatory properties, Limonene (found in Lemons) aids with digestion, and Pinene (found in Pine trees) relieves pain and is an antioxidant. 

Full spectrum CBD extract also contains a very low amount of the cannabis plant's most prominent and psychoactive cannabinoid, THC, usually around 0.2-0.3%.

This tiny amount of THC acts like an undetectable flicking of a switch in your brain.
It mimics the action of anandamide (a neurotransmitter naturally produced in the human body) by binding to CB1 receptors in the endocannabinoid system.

Because they “latch onto” and strengthen your body’s endocannabinoids, many people report that they experience a lower overall intensity of pain.
This makes full spectrum CBD become even more powerful!

When all these components come together; CBD, THC and terpenes produce what is known as an entourage effect; A symbiotic friendship between CBD and terpenes which has been shown to increase the healing properties of each.

So, as you may be able to tell, there is a lot more value to full spectrum CBD extracts. CBD isolate may be more pure, however the absence of the entourage effect makes CBD isolate less powerful in comparison.


Which is better? CBD isolate or full spectrum CBD? The scientific facts

An interesting study by the Lautenberg Center for General and Tumor Immunology in Jerusalem was Published in the journal Pharmacology & Pharmacy in 2015 (1).

The study examines “The effectiveness of administering isolated cannabinoid extracts (a CBD-only formula) versus whole plant extracts (which contain the full range of the plant’s cannabinoid content)”.
They managed to acquire a CBD-rich strain of cannabis called Avidekel from an Israeli medical cannabis producer. The plant referred to as “Clone 202”, was used to extract the CBD-rich oil which consisted of 17.9% CBD. This was used in both the CBD isolate and full spectrum CBD testing. 

The CBD isolate tests confirmed that “a single-molecule CBD administration generated a bell-shaped dose-response curve with a narrow therapeutic window”

Basically, the dose that helps users is very specific, and the time it lasts isn’t very long. If you do too little, you miss your dose. If you do too much, you miss your dose. The window of efficacy for an isolate is very small. Not exactly ideal for the mass market and making happy customers.

But a different dose response pattern was observed when the clone 202 extract was administered.

Rather than showing a bell-shaped curve, where a therapeutic effect could only be achieved at a certain concentration of pure CBD, the whole plant CBD-rich extract caused a direct, dose-dependent inhibition of pain and inflammation.

The clone extract provided a clear correlation between the dosage taken and the anti-inflammatory and anti-nociceptive responses; with increasing responses upon increasing doses.

That means that your dose of full spectrum CBD is likely beneficial to you even if your dose isn’t absolutely correct. In fact, no one knows exactly what the correct dose actually is, making the advice ‘start low, go slow’ very relevant.

The conclusion of the study was that the whole plant extract, which contained a large percentage of CBD, but also contained traces of the other cannabinoids, proved far more effective than CBD-only solutions in alleviating inflammation and pain sensation.

Is full spectrum CBD extract safe?

It is undoubtedly safe. It is impossible to overdose from full spectrum CBD products.

It exerts absolutely no negative side effects. Whether it is combined with prescription drugs or administered by itself the consumer doesn’t have to worry about any negative effects.
 
In fact, many people who take full spectrum CBD oil report an increase in mental focus. This is because of the anti-anxiety properties that CBD offers. Less anxiety means more focus.

CBD isolate sounds useless after reading that… Does CBD isolate work?

Absolutely! The fundamental effects of CBD still take place, it just might take a different dose compared to its efficient friend, full spectrum CBD, that works effectively in most doses.

A good way to get the most of your CBD isolate is to use a small amount of full spectrum extract alongside it. Your distillate will last longer, and your isolate will be supercharged with the benefits of the full plant spectrum power!

There are some advantages to the sole use of CBD isolate, however.

For those that want to “play it safe”, and not run the risk of having any potential psychological side effects of THC, or fail a drugs test at work (although both of these instances are very unlikely) CBD isolate will be the best option.

Another benefit of CBD isolate is its flexibility of use.
As it is an odorless, tasteless white powder, it can be incorporated into lots of products that you can make yourself at home.

For example you could add it to a ‘carrier’ oil or cream to use as a topical solution. This is great to use on scarred or irritated skin.
But keep in mind, when using it topically, more CBD doesn’t mean more effective. In fact a lower concentration in your CBD isolate cream or oil has a better effect on your skin.

The uses for CBD isolate don’t stop there, though! You can add it to your morning juice or smoothie, or to honey to mix with your tea and coffee. The possibilities are endless!

 

To round it off, each form of CBD has their own unique benefits. While both can be effective at achieving your desired outcomes, each person’s preferences come into play, and are relevant to the extensity of the issues that person is trying to remedy.

We recommend testing the waters to see which type of CBD extract works best for you.
Experiment with different dosages, and trial different products until you find what is the most effective for your needs.


 

References

(1) Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
Authors - Ruth GallilyZhannah YekhtinLumír Ondřej Hanuš

CBD and Anxiety

CBD and Anxiety

Depending on who you are, you might have heard that CBD has a wide array of health benefits. There has been a recent surge of interest in the cannabis derived compound named CBD, and it is only now that this interest is being backed and investigated by students in universities and scientists in laboratories all over the world.

At first, many were skeptical. People thought that a natural compound, let alone a cannabis-compound, could effectively treat such a wide range of conditions. But as the years went on, medical researchers learned more, and the success stories of tens of thousands of users stacked up. The truth was undeniable, CBD truly can work!
 
In this article we will be exploring one of the many issues CBD can help with - anxiety.

What is Anxiety?

Anxiety is one of the most common emotional and behavioural problems in our society. In fact, a 2017 report released by the World Health Organisation suggests nearly 264 million people are living with anxiety worldwide.
To put it simply, anxiety is a condition characterised by restlessness and excessive worry. Those of us who are dealing with it usually have a hard time making decisions, speaking in public, tolerating criticism, or asking our boss for a raise. If this sounds familiar to you, you, like many others, have suffered from anxiety.

As you can imagine, researchers and healthcare professionals from all around the world are in a constant search for new ways to help people manage stress and anxiety.
However, it is not just those in the healthcare sector that are keen to explore these new avenues of medication. Small-scale enthusiasts, and even big corporate companies, are also looking for their share of this new and exciting industry.

This has created an open market with a plethora of opportunities available, making the choices present to consumers, quite frankly, daunting.

How does it feel to have CBD help with anxiety?

When we become stressed, our brain releases cortisol
, which is the compound responsible for how we feel when we are stressed. Cortisol can be helpful when we need to react quickly to a dangerous situation, however too much disrupts the natural balance of our body and mind which can result in serious health problems.
When certain endocannabinoids, like those in CBD, are introduced into the body, it not only helps provide anxiety relief, it helps us manage our perception of anxiety so that we can look at the situation with a clear mind, and make the best decision.


On a personal note, I experienced the benefits of CBD for around 15 years, but it had always been tied with the benefits (and hindrances) of THC. THC rich breeds of cannabis have been known to make some people feel anxious, I was one of those people. When CBD products exploded in 2016, I started vaping CBD e-liquid and I instantly fell in love with the plant, all over again.

The first time I tried CBD was in e-liquid form. I had a few good blasts on my vaporiser and my anxiety dissolved in a matter of minutes.
I could feel the CBD relax my body and mind without the disorientating head fog that I was normally used to when smoking cannabis containing THC.
Most importantly; Zero anxiety. Subtle waves of relaxation flowed over my body from head to toe. I could feel my mind take a sigh of relief.
An hour before I started vaping the CBD e-liquid, I was somewhat anxious about my impending job interview the next day. It was an important interview that I knew would challenge me. All of my anxieties transformed into quiet confidence. Even the next day at my interview, I was surprisingly calm. I think that was down to my CBD session the night before. And yes, I got the job!


No THC, no problem

In the medical world, “getting high” from the effects of THC is often classed by many as a negative side effect. In medical terms, “getting high” is no different to the side effects of strong painkillers or anti-anxiety medication because the side effects are surprisingly similar; Drowsiness, restlessness, impaired mental functioning and anxiety to name a few.
Driving is out of the question when under the influence of THC, as is operating machinery or anything that requires a moderate amount of responsibility.
With CBD products, these negative effects are absent. There are no nasty side effects, nor are there impaired mental functions, yet all the medicinal properties of the plant are present.

Typical anti-anxiety drugs like Valium and Benzodiazepines that are prescribed to patients come with a long list of side effects; Anything from drowsiness and dizziness, to intense nightmares and weight gain. CBD, on the other hand seems to have very few negative side effects. Because it’s natural, and less intensive in comparison to chemical based drugs often prescribed for anxiety, the body responds to CBD in a way that makes it easier for the consumer to deal with.

The Science behind it all

Now is a good time to look at the facts...

There has been a recent surge in scientific publications that have found preclinical and clinical evidence documenting value for CBD in some neuropsychiatric disorders, including epilepsy, anxiety, and schizophrenia. Evidence points toward a calming effect for CBD in the central nervous system. Interest in CBD as a treatment of a wide range of disorders has exploded.


In a significant study; CBD was shown to be helpful for decreasing anxiety through a simulated public speaking test at doses of 300 mg to 600 mg in single-dose studies. The results are in agreement with evidence from preclinical studies and support the view that CBD induces acute anxiolytic (a drug that reduces anxiety) effects in humans. However, these findings stress the importance of the careful choice of dose ranges when investigating the potential therapeutic effects of CBD. (1)
To be sure of its effects, arterial systolic and diastolic pressure, and heart rate were analysed with a repeated-measures analysis of variance.

So, to break that down into an easily digestible sentence. CBD is proven to reduce anxiety (and lower the heart rate), as long as the dose is right. The sweet spot seems to be around 300mg.

small conducted in 2010 study found that CBD could reduce symptoms of social anxiety in people with social anxiety disorder (SAD). Brain scans of participants revealed changes in blood flow to the regions of the brain linked to feelings of anxiety after consuming CBD. (2)

Also, a 2015 analysis of previous studies concluded that CBD is a promising treatment for numerous forms of anxiety, including social anxiety disorder, panic disorder, obsessive-compulsive disorder, generalised anxiety disorder, and post-traumatic stress disorder. Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile. (3)


The best ways to consume CBD for anxiety relief

The most effective ways to consume CBD is either by using a tincture (an oil-based product that is dropped under the tongue), or by vaping CBD infused e-liquid. Tinctures takes a while to have an effect, sometimes up to an hour. This is because when it’s ingested, it takes time to be absorbed into your blood stream from your stomach. Once it starts to work however,
the effects last substantially longer due it’s time spent in the digestive system
Vaping CBD e-liquid is the quickest form of delivery, sometimes only a few minutes. This is down to your lungs processing the CBD and sending it into the blood stream almost instantly. The effects come quicker, however don’t last quite as long as ingesting it.
Using vaping as a method of delivery is perfect for those people that need a fast acting solution to an anxiety related problem, be it at home or on the go. People often have a few puffs on their CBD e-liquid before business meetings or social events to quickly take the edge off their anxieties. Because CBD e-liquid doesn’t smell any different to other e-liquid, it can be discreetly consumed without any concern or worry.

Conclusion

It seems clear that CBD can help with anxiety. First-hand experiences from people that suffer with anxiety issues show that CBD helps them. The research and experiments also show that CBD consumption changes the function of the brain as well as lowering the heart rate, which in turn facilitates the reduction of anxiety.
It is a safe and natural alternative to the strong chemical-based medication being prescribed to millions of patients. Nature is nicer in this case!
CBD shots can be bought in a variety of strengths which allows you to control your dose depending on your situation. 250mg is a great starting point for everyone.

 

 

 

(1) Zuardi AW, Rodrigues NP, Silva AL, et al. Inverted U-shaped dose-response curve of the anxiolytic effect of cannabidiol during public speaking in real life. Front Pharmacol. 2017 May 11;8:259. doi: 10.3389
(2)
Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report:
José Alexandre S CrippaGuilherme Nogueira DerenussonThiago Borduqui Ferrari


(3)
Cannabidiol as a Potential Treatment for Anxiety Disorders: Esther M Blessing